Cancer continues to be a major global health challenge, with rising incidence and significant mortality, highlighting the need for safer and more effective therapeutic approaches. Traditional medical systems such as Siddha Medicine offer holistic treatment strategies that utilize plant-based remedies with multi-targeted actions. Boerhavia diffusa (Punarnava) is a widely used medicinal herb known for its rejuvenating and disease-modifying properties in traditional practice.

Recent experimental studies have revealed that Boerhavia diffusa exhibits notable anticancer activity through multiple mechanisms, including antioxidant defence, immune system modulation, inhibition of tumour cell proliferation, and suppression of metastasis. Its diverse phytochemical profile contributes to these biological effects, making it a promising candidate for integrative cancer therapy.