Logo
International Journal of
Pharmaceutical Science and Research
ARCHIVES
VOL. 11, ISSUE 2 (2026)
Formulation development and evaluation of luliconazole based emulgel for topical application
Authors
Niraj Saini, Dr. Manmohan Sharma, Anil Ahuja, Shashank Kumar Tiwari
Abstract
The aim of the current study was to develop emulgel formulation of Luliconazole that was both stable and efficacious. Luliconazole is a member of the antifungal medication class. The antifungal activity of luliconazole is strongest against Trichophyton species, Aspergillus fumigatu, Malassezia species, and Candida albicans which are the main causes of dermatophytosis. Nevertheless, luliconazole has disadvantages such lower skin retention and low aqueous solubility and poor skin penetration due to its classification as BCS Class II. The current study's goal was to develop and evaluate the emulgel system for luliconazole employing two distinct gelling agents: Carbopol 934 and HPMC K 15M with varying concentration of Light liquid paraffin and emulsifying agents. Evaluation parameters like ph, viscosity, spreadability, extrudability, drug content determination and in vitro drug release at 12 hours were carried out. On the basis of results FH3 emulgel which is HPMC K 15 M based was found to be best. Zero order drug release with non fickian diffusion kinetics was found to be the release mechanism. For physicochemical parameters, such as appearance, pH, drug content, no significant changes were observed periodically for 90 days, when compared with the initial results ensuring FH3 stability.
Pages:14-21
How to cite this article:
Niraj Saini, Dr. Manmohan Sharma, Anil Ahuja, Shashank Kumar Tiwari "Formulation development and evaluation of luliconazole based emulgel for topical application". International Journal of Pharmaceutical Science and Research, Vol 11, Issue 2, 2026, Pages 14-21
Download Author Certificate

Please enter the email address corresponding to this article submission to download your certificate.