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VOL. 11, ISSUE 1 (2026)
Pharmacological comparison of digoxin and captopril in the management of congestive heart failure: Evidence from a clinical meta-analysis
Authors
Sandeep Goyal, Rakesh Chawla, Vijender Kumar, Pranav Goyal
Abstract
Congestive heart failure (CHF) is a major
health problem that affects people all over the world since it makes people
sick, costs more money for healthcare, and kills more people. Making sure that
medications work well is really important for helping people get better.
Digoxin, a cardiac glycoside that is recognized for its positive inotropic
effects, and captopril, an angiotensin-converting enzyme (ACE) inhibitor, are
two medications that are widely used to treat congestive heart failure (CHF). A
number of studies have been done on how each of these drugs works to treat CHF.
The aim of this systematic review and meta-analysis was to examine and compare
the safety and efficacy of digoxin and captopril in individuals with congestive
heart failure (CHF). The study concentrated on clinical outcomes, particularly
the exacerbation of congestive heart failure (CHF), the frequency of angina
episodes, and the adverse effects observed after treatment. We examined
extensive recent literature and utilized internet databases such as PubMed,
MEDLINE, Elsevier, ScienceDirect, and the Cochrane Library to identify
randomized controlled trials published from 2000 to 2022. There were rules
about which studies might be included and which could not. We then used Review
Manager (RevMan 5.4) and SPSS version 26 to look at the data. The combined
analysis demonstrated that digoxin substantially extended the duration prior to
the exacerbation of CHF in comparison to captopril, with a mean difference of
−32.37 (95% CI −48.60 to −16.14; P < 0.00001). Both digoxin and captopril
worked better than a placebo. They worked significantly better when given
together. The research examined in this review indicated that digoxin had a low
incidence of side effects. The results demonstrate that digoxin is still a
beneficial drug for persons with CHF who wish to get better, especially by
slowing down the progress of their disease. Captopril, on the other hand, is
superior since it modifies how hormones work in the brain. But we need
additional big, randomized controlled trials to back up these findings and
improve CHF treatment.
Pages:112-119
How to cite this article:
Sandeep Goyal, Rakesh Chawla, Vijender Kumar, Pranav Goyal "Pharmacological comparison of digoxin and captopril in the management of congestive heart failure: Evidence from a clinical meta-analysis". International Journal of Pharmaceutical Science and Research, Vol 11, Issue 1, 2026, Pages 112-119
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