Hypertension is one of the most prevalent non-communicable diseases and a major risk factor for cardiovascular morbidity and mortality worldwide. Effective pharmacological management is essential to control blood pressure and prevent complications such as stroke, myocardial infarction, and renal failure. Drugs acting on the renin–angiotensin–aldosterone system (RAAS), including Captopril and Candesartan, are widely used for the treatment of hypertension. However, variations in efficacy, safety, and tolerability between these agents remain a subject of clinical interest. The present study aimed to compare the efficacy and safety of captopril and candesartan in hypertensive patients through a systematic review and meta-analysis of available clinical studies. A comprehensive literature search was conducted using major electronic databases to identify clinical studies comparing captopril and candesartan in patients with hypertension. Eligible studies were screened according to predefined inclusion and exclusion criteria. Data related to systolic blood pressure (SBP), diastolic blood pressure (DBP), treatment duration, and adverse drug reactions were extracted and analyzed. Quantitative synthesis was performed using meta-analysis methods to evaluate pooled treatment effects.