ARCHIVES
VOL. 11, ISSUE 1 (2026)
Composition of ampicillin determined by IR spectroscopy
Authors
Ioana Stanciu
Abstract
In this article, we determined the composition
of ampicillin by IR spectroscopy using a Bruker spectroscope. The IR spectrum
of ampicillin contains bands between wavelengths of 4000cm-1 and
450cm-1. The functional groups in the composition of ampicillin are:
N-H, COO, OH, N-C, C=C. Ampicillin is a semisynthetic antibiotic of the
penicillin class, belonging to the aminopenicillin subgroup. Its chemical
composition is based on the beta-lactam nucleus characteristic of penicillins,
formed by a beta-lactam ring fused to a thiazolidine ring. An aminobenzyl side
chain is attached to this skeleton, which confers extensive antibacterial
activity against Gram-negative bacteria, while maintaining efficacy against
many Gram-positive bacteria. Ampicillin is usually formulated in salt form
(e.g., ampicillin trihydrate or ampicillin sodium) to improve its stability and
solubility. From a pharmaceutical point of view, preparations may include
excipients such as stabilizing agents, diluents and substances for pH
adjustment, depending on the pharmaceutical form (capsules, tablets, injectable
powder). Its structural and pharmacological properties allow ampicillin to
inhibit bacterial cell wall synthesis, which leads to its bactericidal effect.
Pages:46-47
How to cite this article:
Ioana Stanciu "Composition of ampicillin determined by IR spectroscopy". International Journal of Pharmaceutical Science and Research, Vol 11, Issue 1, 2026, Pages 46-47
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.