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International Journal of
Pharmaceutical Science and Research
ARCHIVES
VOL. 11, ISSUE 1 (2026)
Impact of dehydration technologies on the stability of bioactive compounds in Opuntia ficus-indica powder: Implications for functional food development
Authors
Vo Thi My Nga
Abstract
Opuntia ficus-indica (OFI) cladodes have emerged as a promising plant-based ingredient for functional food and nutraceutical applications due to their high content of thermolabile bioactive compounds, including betalains, vitamin C, and high-molecular-weight mucilage. These constituents collectively contribute to antioxidant activity, modulation of postprandial glycemia, and gut health. However, the high moisture content and water activity of fresh cladodes necessitate dehydration to ensure microbial stability and industrial usability. Dehydration, while essential, imposes thermal, oxidative, and mechanical stresses that may compromise molecular integrity and functional performance. This work critically examines the impact of major dehydration technologies—lyophilization, spray drying, and convective hot-air drying—on the physicochemical stability of OFI bioactives and their functional implications, particularly in the context of Type 2 Diabetes Mellitus (T2DM). Special emphasis is placed on the preservation of the arabinogalactan–protein (AGP) mucilage complex, which governs rheological behavior and glucose diffusion retardation in the gastrointestinal tract. Accumulated evidence indicates that lyophilization provides superior retention of betalains (>90%), vitamin C, and mucilage viscosity by minimizing thermal and oxidative degradation and preserving porous microstructure. In contrast, convective hot-air drying promotes Maillard reactions, oxidative loss of antioxidants, and polysaccharide depolymerization, leading to diminished functional efficacy. Optimized spray drying, particularly when employing low-glycemic carriers such as inulin, represents a viable compromise between quality preservation and industrial feasibility. The review highlights the necessity of aligning dehydration technology and formulation strategies with targeted health claims to ensure the development of evidence-based functional foods.
Pages:11-17
How to cite this article:
Vo Thi My Nga "Impact of dehydration technologies on the stability of bioactive compounds in <i>Opuntia ficus-indica</i> powder: Implications for functional food development". International Journal of Pharmaceutical Science and Research, Vol 11, Issue 1, 2026, Pages 11-17
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