ARCHIVES
VOL. 10, ISSUE 2 (2025)
Epigenetic mechanisms involved in toxicity induced by the environmental factors
Authors
Pragati Kumari Gupta, Rakesh Mohan, Ajeet Kumar, Hafizurrahman
Abstract
A large number of toxicants and their by-products present in the
environment pose a lethal and detrimental effect on the living population.
Different mechanisms are involved in the neutralization of their toxic effects.
The mechanism of detoxification depends on the chemical and biological
composition of the compounds. They affect the gene expression level by altering
the DNA and histone modification patterns by affecting the recruitment of
various transcription machinery. These alterations are termed as epigenetic
modifications. Compounds and toxicants reported to cause epigenetic alterations
are heavy metal, Benzene, Bisphenol A, Dioxins, TCA and a number of other
chemicals. Exposure to these factors may result in the predisposition of the
altered epigenetic modifications from one generation to another. Dysregulation
of gene expression governed by epigenetic alterations induced by exposure to
toxicants results in developmental abnormalities. In this review, the common
epigenetic modifications caused by toxicants and their role in development and
progression of diseases is discussed. This would help better understand the
toxic effects of the various factors responsible for the development of chronic
diseases and their predisposition in the future generation. It also provides an
insight into the therapeutic strategies to prevent adverse effects of
toxicants.
Pages:106-111
How to cite this article:
Pragati Kumari Gupta, Rakesh Mohan, Ajeet Kumar, Hafizurrahman "Epigenetic mechanisms involved in toxicity induced by the environmental factors". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 106-111
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.