ARCHIVES
VOL. 10, ISSUE 2 (2025)
Evaluation of anxiolytic and antidepressant potential of hydroalcoholic extract of Cordyline fruticosa in mice
Authors
Noumi Patidar, Yashraj Yadav, Dishant Gupta, Raksha Goswami, Sohan S Chouhan, Sunita Patidar
Abstract
Anxiolytics and antidepressants are closely
related because anxiety and depression often occur together and share similar
brain pathways. Antidepressants reduce anxiety over time without the dependence
risks associated with anxiolytics, making them the preferred long-term option,
while anxiolytics are mainly used for acute or short-term symptom control. The
use of medicinal plants in the treatment of mental diseases is a reality that
has accompanied civilizations throughout history, and there are numerous
species having pharmacologically confirmed central effects. Then, this
study assessed the anxiolytic and antidepressant potential of the
hydroalcoholic extract of Cordyline fruticosa (HECF) leaves in mice. Cordyline fruticosa
significantly increased the proportion of entry into open arms at 200 mg/kg (p
< 0.01), but not at 100 mg/kg, compared to the control group. The effects of
different doses of hydroalcoholic extract of Cordyline fruticosa (HECF)
on the entries into the close arms. Biostatic analysis revealed that Cordyline
fruticosa significantly increased the immobility in both test (FST and TST)
at 200 mg/kg (p < 0.05), but not at 100 mg/kg, compared to the control
group. Based on the aforementioned findings, it was determined that Cordyline
fruticosa hydro-alcoholic leaf extract possesses strong anxiolytic and
depressive properties. When compared to control, both the 100 and 200
mg/kg dose levels of Cordyline fruticosa showed statistically
significant anxiolytic and antidepressant effects in all parameters.
Pages:99-105
How to cite this article:
Noumi Patidar, Yashraj Yadav, Dishant Gupta, Raksha Goswami, Sohan S Chouhan, Sunita Patidar "Evaluation of anxiolytic and antidepressant potential of hydroalcoholic extract of <i>Cordyline fruticosa</i> in mice". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 99-105
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