This study examines poor diet, urbanization and other modern styles of life have resulted in the increase in diseases around the world. These factors are a major risk to human health. Among fruits, mulberry is the most appreciated for its nutritional and economic significance. It has been investigated for various health benefits. Mulberry is rich in bioactive compounds that bolster the body's immune system and contribute to preventing hyperlipidaemia, hyperglycemia, liver disorders, microbial infections and abnormal cell growths. There remains a lack of credible and unified evidence regarding the bioactive components in mulberry and their mechanisms of action, although they show promising potential. More and intensified research on mulberry based-products is required to improve the value of the product. It highlights the therapeutic activity of mulberry, discusses how it can prevent and treat chronic diseases, and describe potential applications in functional foods as well as laboratory studies. The discoveries reported in this review form an essential basis for future investigations, novel strategies and successful application of mulberry and its components including prevention of diseases.