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VOL. 10, ISSUE 2 (2025)
Phytosomes: A Modern Lipid-Based Approach to Enhance the Bioavailability of Phytoconstituents
Authors
Nida Afzal Ahmed, Dr. Vineet Jain
Abstract
Phytosomes represent a modern and efficient
lipid-based drug delivery approach that significantly improves the absorption
and therapeutic efficacy of plant-derived bioactive compounds. Many
phytoconstituents from medicinal plants exhibit promising pharmacological
effects but are limited by poor solubility, instability, and low
bioavailability when administered orally. Phytosome technology overcomes these challenges
by forming molecular complexes between phytochemicals and phospholipids—most
commonly phosphatidylcholine—enhancing their lipophilicity and facilitating
better cellular uptake. This review provides an in-depth discussion of
phytosome formulation strategies, characterization techniques, pharmacokinetic
advantages, therapeutic applications, and current challenges in formulation
development. Various preparation methods such as solvent evaporation,
anti-solvent precipitation, lyophilization, and supercritical fluid techniques
are examined. Additionally, the review explores quality control aspects,
stability considerations, and future directions integrating nanotechnology,
green chemistry, and personalized medicine approaches. Collectively, phytosomes
bridge the gap between traditional herbal therapy and modern pharmaceutical
science by improving the clinical potential of natural compounds.
Pages:67-72
How to cite this article:
Nida Afzal Ahmed, Dr. Vineet Jain "Phytosomes: A Modern Lipid-Based Approach to Enhance the Bioavailability of Phytoconstituents". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 67-72
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