ARCHIVES
VOL. 10, ISSUE 2 (2025)
Pharmacognostic evaluation and in-vivo anti-inflammatory effects of Curcuma Longa leaves extract in animal model
Authors
Rakesh Kumar Niranjan, Manish Thimmaraju, Jitendra Kumar Malik, Vivek Gupta, Gyan Singh
Abstract
The research paper examines the
pharmacognostic assessment, as well as the in-vivo anti-inflammatory
properties of Curcuma longa leaf extract on an animal model. Curcuma
longa leaves are traditionally known as rhizomes but have not been properly
studied even though they may have some medical benefits. Based on the
pharmacognostic tests, namely organoleptic, microscopic, physicochemical, and
fluorescence analysis, the study identifies the phytochemical composition of
the leaves to show the presence of bioactive compounds, including flavonoids,
alkaloids, and phenols. Quantitative measurements point towards the high levels
of phenolic compounds (42.5mg GAE/g) and flavonoids (30.7mg QE/g). The
anti-inflammatory properties of the leaf extract were compared in-vivo
in Swiss albino mice by the carrageenan-induced paw edema. This showed a
dose-dependent decrease of paw edema and the highest decrease was observed at
the doses of 800mg/kg, which was equivalent to aspirin. Moreover, the extract
had also a good safety profile, and no toxicity was detected at the highest
dose tested (8 g/kg). These results give credence to Curcuma longa
leaves having therapeutic value as a natural anti-inflammatory substance and as
an alternative to synthetic anti-inflammatory medications, which have fewer
side effects. The research should be followed up in the future with clinical
trials to understand the complete pharmacological processes of the extract and
their utilization in the treatment of inflammatory-related diseases.
Pages:55-60
How to cite this article:
Rakesh Kumar Niranjan, Manish Thimmaraju, Jitendra Kumar Malik, Vivek Gupta, Gyan Singh "Pharmacognostic evaluation and <i>in-vivo</i> anti-inflammatory effects of <i>Curcuma Longa</i> leaves extract in animal model". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 55-60
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