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VOL. 10, ISSUE 2 (2025)
Evaluation of wound healing activity of Opuntia Ficus Indica thron extract on wistar Albino Rat
Authors
Payal Songare, Sohan Singh Chouhan, Raksha Goswami, Yashraj Yadav
Abstract
Traditionally, Opuntia ficus indica is used for
wound-healing activity. There are currently no detailed scientific data
available regarding the wound-healing activity of Opuntia ficus-indica.
Opuntia ficus-indica, the present study was designed to explore the effect
of ethanolic thorn extract of Opuntia ficus indica (OFI) on
experimentally induced excision and incision wound models in Wistar rats. The
wound-healing efficacy of ethanolic extracts of Opuntia ficus indica
was evaluated in excision and incision wound models by topically applying the
ethanolic extract in the form of ointment as per the Indian Pharmacopoeia. The
extract was formulated in an ointment base at concentrations of 5% and 10% and
topically applied to the wounds. In the excision and incision wound model,
topical application of different concentrations of Opuntia ficus indica
extract ointment (5% and 10% w/w extract in the simple ointment) has shown a
high rate of wound contraction and decrease in the period of epithelization
time and improved the tensile strength to a greater extent when compared to the
control (simple ointment treated) group. The 10% extract ointment-treated group
demonstrated greater wound-healing-promoting property than the 5% extract
ointment-treated animals. In the excision wound model, the animals showed a
significant reduction in the period of epithelization and improved wound
contraction, whereas the increase in the breaking strength was evident from the
incision model. The results suggest that the ethanolic thorn extract of Opuntia
ficus indica (OFI) possesses wound-healing properties when applied
topically.
Pages:33-37
How to cite this article:
Payal Songare, Sohan Singh Chouhan, Raksha Goswami, Yashraj Yadav "Evaluation of wound healing activity of <i>Opuntia Ficus Indica</i> thron extract on wistar Albino Rat". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 33-37
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