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VOL. 10, ISSUE 2 (2025)
Evaluation of anti-diabetic and antihyperlipidemic activity of hydro-alcoholic extract of Alternanthera sessilis root
Authors
Ritu Solanki, Sohan Singh Chouhan, Yashraj Yadav
Abstract
Diabetes mellitus is a dangerous, chronic metabolic illness defined by
high blood sugar levels caused by either insufficient insulin production by the
pancreas or ineffective insulin utilization by the body. Type 2 Diabetes
Mellitus (T2DM) accounts for about 90% of all diabetes diagnoses in adults. As
of 2025, the global epidemiology of diabetes mellitus reflects a growing and
urgent public health crisis. The number of people living with diabetes
worldwide has surged to approximately 830 million, a dramatic increase from
1500 million in 2030Alternanthera sessilis dried root was ground into a
fine, coarse powder using an electric laboratory blender. Alternanthera
sessilis powder was macerated in ethanol and water (hot maceration in a
70:30 v/v ratio) to complete the extraction. The hydroalcoholic extract of Alternanthera
sessilis root (HEAS) was cooled and stored in a well-closed container in a
dry state. The "Fixed Dosage Method" of the OECD 423 guideline was
utilised in the current investigation to determine the acute toxicity of the
substance In this study, 16-week-old normal (fasting blood glucose level of
90–110 mg/dl) rats were used. A single dose of intraperitoneal injection of STZ
(55 mg/kg/i. p) dissolved in 0.1M citrate buffer (pH 4.5) was used to induce
diabetes in overnight fasted male wistar rats weighing 170–200 gm. Biochemical
analysis and Estimation of serum lipid profile was done after 28th
days. The blood sugar levels in these rats stayed high and did not
decrease much during the same period. The larger drop in blood sugar levels in
the Group IV rats shows that HEAS 200 was effective in lowering blood sugar.
The results point to the potential benefits of using HEAS 200 as a natural way
to manage blood sugar. This suggests that Alternanthera sessilis
extracts could be an exciting option for new herbal medicines aimed at treating
diabetes and related conditions like abnormal lipid levels which is called
dyslipidaemia.
Pages:14-20
How to cite this article:
Ritu Solanki, Sohan Singh Chouhan, Yashraj Yadav "Evaluation of anti-diabetic and antihyperlipidemic activity of hydro-alcoholic extract of <i>Alternanthera sessilis</i> root". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 14-20
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