ARCHIVES
VOL. 10, ISSUE 2 (2025)
Formulation and assessment of a topical gel containing voriconazole for the management of fungal infections
Authors
Prateek Singh Panwar, Yasmeen Ghori, Dr. Govind Soni
Abstract
The current research project was dedicated to
the design, optimization, and comprehensive evaluation of a topical gel
formulation containing voriconazole for the management of superficial fungal
infections. Voriconazole, a potent broad-spectrum antifungal agent belonging to
the imidazole class, is well-documented for its efficacy against a wide range
of fungal pathogens. It is classified under the Biopharmaceutical
Classification System (BCS) Class II, which denotes low aqueous solubility
combined with high membrane permeability. Despite its favorable oral
bioavailability (approximately 90%), systemic administration of voriconazole is
often accompanied by dose-limiting toxicities, including hepatic dysfunction
and renal impairment. These concerns have prompted the need for alternative
drug delivery approaches. Thus, the present study sought to develop a topical
drug delivery system capable of providing localized therapeutic action at the
site of infection, while simultaneously minimizing systemic absorption and
enhancing patient adherence to antifungal therapy
Pages:8-13
How to cite this article:
Prateek Singh Panwar, Yasmeen Ghori, Dr. Govind Soni "Formulation and assessment of a topical gel containing voriconazole for the management of fungal infections". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 2, 2025, Pages 8-13
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.