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VOL. 9, ISSUE 2 (2024)
Formulation and evaluation of in-situ gels of hydrocartisone for the treatment of mouth ulcer
Authors
Vaibhav Joshi, Shabnam Khan, Shweta Shriwas, Ramakant Sharma, Rakesh Patel
Abstract
The present work was aimed to develop a in-situ gels and films of
hydrocortisone for the treatment of aphthous ulcer. The in-situ gels and film
was developed by using methylcellulose, based on the concept of temperature
dependant gelling system. The sol-to-gel transformation occurred during the
reduction of temperature. The in-situ gels were evaluated for gelling capacity,
drug content, viscosity & in-vitro release were as in the film its
evaluated for tensile strength, folding endurance, thickness etc. The
experimental part shows that viscosity of the sol was increased by increasing
the concentration of polymer. All the results were found to be satisfactory,
when compared between the in-situ gels and films. The has shown the best
formulation because of their therapeutic efficacy and provided sustained
release of the drug over a period of time. These results demonstrate that the
developed system is an alternative to conventional drug delivery system,
patient compliance, industrially oriented and economical.
Pages:54-58
How to cite this article:
Vaibhav Joshi, Shabnam Khan, Shweta Shriwas, Ramakant Sharma, Rakesh Patel "Formulation and evaluation of in-situ gels of hydrocartisone for the treatment of mouth ulcer". International Journal of Pharmaceutical Science and Research, Vol 9, Issue 2, 2024, Pages 54-58
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