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VOL. 9, ISSUE 2 (2024)
Formulation strategies and excipient selection based on the biopharmaceutics classification system of drugs
Authors
Krishna Maniyalil
Abstract
The Biopharmaceutical Classification System is
an Essential and Helpful tool for getting the Waivers for In vivo-
bioequivalence research. It is also Useful in the process of New drug Candidate
For Formulation. As per the BCS classification system, classes I, II, III, and
IV are classified as solubility and permeability factors Class I refers to High
solubility- High permeability, class II refers to Low solubility- High
permeability, class III refers to High solubility- Low permeability and class
IV refers to low solubility- low permeability For BCS class I drugs,
Conventional dosage Forms are suitable, like Immediate-release Tablet, Class II
Formulation strategies Focus on Reduction of Particle Size where it includes
Salt forms to Solid dispersion. Where Niosomes, Nano-emulsion are the preferred
for class III drugs, Class IV drugs are considered to be challenging class as a
drug having low solubility and low permeability. Lipid-based drug delivery
system, Self-Emulsifying drug delivery system Preferred. The present review is
focused on Study of different suitable Excipient Selection criteria for all
four categories, which Mentioned, could help find the collective data on BCS, where
Different Excipient Criteria are used in Formulations
Pages:36-40
How to cite this article:
Krishna Maniyalil "Formulation strategies and excipient selection based on the biopharmaceutics classification system of drugs". International Journal of Pharmaceutical Science and Research, Vol 9, Issue 2, 2024, Pages 36-40
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