ARCHIVES
VOL. 9, ISSUE 2 (2024)
In vitro Hyaluronidase inhibitory investigations of Abies Webbiana Roots
Authors
Mukesh Suniya, Ranjeet Kumar Jha, Monika Bansal, Jaspreet Kaur
Abstract
A. webbiana
has a long tradition of utilization in the treatment of heart diseases, cough,
inflammation, tumour, amoebiasis, hypochlorhydria, vomiting, antispasmodic,
aphrodisiac, diuretic and mouth disorders yet has not been systematically
assessed to approve its conventional cases. Hence, the current examinations
were attempted so as to assess A. webbiana aerial parts efficiently for
hyaluronidase inhibitory activity. The chloroform and methanol extracts of
plant aerial parts was prepared in a Soxhlet mechanical assembly with
chloroform and methanol, respectively, subsequent to defatting with petroleum
ether. Preliminary phytochemical screening of various crude extracts suggested
that petroleum ether extract showing presence of fixed oil; chloroform extract
showing presence of steroids, alkaloids, triterpenoids; methanol extract
showing presence of tannins, flavonoids and water extract showing presence of
carbohydrates, proteins. The methanol extract of plant aerial parts exhibited
strong hyaluronidase inhibitory activity followed by respective chloroform
extract and water extract, as compared to standard hyaluronidase inhibitory
drug tannic acid. The water and chloroform extracts almost devoid of tested
pharmacological activity. The available literature also reveals that a large
number of flavonoid and phenolic compounds have been reported to exhibit
hyaluronidase inhibitory activity. The contents of total phenols were found to
be almost three times in comparison to total flavonoids content in methanol
extract. In agreement to these reports, it is suggested from our results that
hyaluronidase inhibitory activity of A. webbiana aerial parts is
attributed to these bioactive groups of phytoconstituents. Finally, it can be
suggested that it is better to isolate main constituents responsible for
hyaluronidase inhibitory activity in future studies using column
chromatography.
Pages:19-23
How to cite this article:
Mukesh Suniya, Ranjeet Kumar Jha, Monika Bansal, Jaspreet Kaur "<i>In vitro </i>Hyaluronidase inhibitory investigations of <i>Abies Webbiana</i> Roots". International Journal of Pharmaceutical Science and Research, Vol 9, Issue 2, 2024, Pages 19-23
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