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VOL. 9, ISSUE 1 (2024)
The impact of pharmaceutical excipients on drug efficacy and metabolism
Authors
Loredana Lupo, Roberto Sasso
Abstract
This research paper explores the significant
yet often underappreciated role of pharmaceutical excipients in the efficacy
and metabolism of drugs. Despite traditionally being considered inert
substances used in drug formulation for bulk, stability, or bioavailability
enhancement, recent evidence suggests that excipients can profoundly influence
drug action and metabolic pathways. Through a comprehensive analysis of both in
vitro and in vivo studies, this paper examines how various
excipients affect drug absorption, distribution, metabolism, and excretion
(ADME) processes. The findings reveal that excipients can alter pharmacokinetic
parameters, modulate the activity of metabolic enzymes, and influence drug
transporter interactions. These interactions can lead to variations in drug
efficacy, therapeutic outcomes, and patient safety. The study underscores the
necessity for a deeper understanding of excipient-drug interactions within the
pharmaceutical sciences, advocating for more thorough evaluation methods during
drug development to predict and mitigate potential alterations in drug behavior
caused by excipients.
Pages:31-33
How to cite this article:
Loredana Lupo, Roberto Sasso "The impact of pharmaceutical excipients on drug efficacy and metabolism". International Journal of Pharmaceutical Science and Research, Vol 9, Issue 1, 2024, Pages 31-33
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