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VOL. 8, ISSUE 4 (2023)
Benidipine hydrochloride fast dissolving sublingual film formulation and evaluation for the treatment of hypertension
Authors
Pratikeswar Panda
Abstract
The sublingual route is extremely beneficial for a rapid onset of
action and improved patient compliance. It increases drug utilization and
active pharmaceutical ingredient efficacy. Patients prefer the oral route the
most. A fast-dissolving oral drug delivery system is a solid dosage form that
dissolves or disintegrates in the mouth in seconds without using water or
chewing. The drug's solubility and bioavailability were improved by using solid
dispersion. Physical mixture was used to create solid dispersions of Benidipine
hydrochloride: β-cyclodextrin in various ratios (1:1, 1:2, 1:3, 1:4). The
current study discusses the formulation aspects, manufacturing methods such as
solvent casting, evaluation parameters, and applications of fast dissolving
films made from polymers such as HPMC E-5, as a film forming agent, Sodium
starch glycolate, as a super disintegrating agent, Critic acid, as a saliva
stimulating agent, PEG 400 as a plasticizer, and Mannitol as a sweetener. This
study concluded that the fast-dissolving sublingual film of Benidipine
Hydrochloride performed better than the marketed formulation, and all
parameters performed satisfactorily.
Pages:1-6
How to cite this article:
Pratikeswar Panda "Benidipine hydrochloride fast dissolving sublingual film formulation and evaluation for the treatment of hypertension". International Journal of Pharmaceutical Science and Research, Vol 8, Issue 4, 2023, Pages 1-6
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