ARCHIVES
VOL. 8, ISSUE 4 (2023)
A review on formulation and evaluation of Cox2 inhibitor
Authors
Aditya Jayram Satpute, Dr. Nitin Mohite, Akash S Nalawade, Manisha H Vite
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used
therapeutic agents that exhibit frequent and sometimes severe adverse effects,
including gastrointestinal ulcerations and cardiovascular disorders. In an
effort to obtain safer NSAIDs we assessed the direct cyclooxygenase (COX)
inhibition activity and we investigated the potential COX binding mode of some
previously reported 2-(trimethoxyphenyl)-thiazoles. The In vitro COX
inhibition assays were performed against ovine COX-1 and human recombinant
COX-2. Molecular docking studies were performed to explain the possible interactions
between the inhibitors and both COX isoforms binding pockets Inflammation is a
complex phenomenon necessary in human defense mechanisms but also involved in
the development of some human diseases. The discovery of cyclooxygenase-2
(COX2) improved the pharmacology of no steroidal anti-inflammatory drugs
(NSAID) giving a clear mechanism for prostaglandin regulation In vivo
and providing a new target for the development of COX-2-selective drugs without
gastrointestinal side-effects. Keeping in view the importance of this
pharmacological class, several literature reports have underlined the impact of
these anti-inflammatory compounds in therapeutics. The present review considers
the most recently published literature concerning COX-2 inhibitors until 2016.
Through a wide chemical classification, the last developments concerning this
therapeutic family by highlighting structure-activity relationships insights
and mechanisms are presented. A summary of the principal adverse effects
observed and an overview of the new potential therapeutic indications for COX-2
inhibitors are also reported.
Pages:7-11
How to cite this article:
Aditya Jayram Satpute, Dr. Nitin Mohite, Akash S Nalawade, Manisha H Vite "A review on formulation and evaluation of Cox2 inhibitor". International Journal of Pharmaceutical Science and Research, Vol 8, Issue 4, 2023, Pages 7-11
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