Objectives: The current investigation was carriedout to determine hypolipidemic potentials of ethanol extract of Rivina humilis against high fat diet induced hyperlipidemia in wistar rats.

Methods: Defatted powdered drug of ariel parts of Rivina humilis was subjected to ethanol extraction using soxhlet extractor. The high fat diet (HFD) induced hyperlipidemia in rat model was used for the present investigation in which all experimental rats were fed with HFD and treated with ethanol extract of Rivina humilis (EERH) for 21 days. Blood samples were collected from all the animals on day 21^st after one hour of administration of the drugs and serum lipid profile (total cholesterol, triglycerides, HDL, LDL and IDL) was estimated. All animals were sacrificed after the blood sampling and liver samples were collected.

Results: The therapeutic rats ingested with extract of Rivina humilis and standard drug atorvastatin have shown significant reduction in serum cholesterol, serum triglycerides, LDL and increase in HDL indicating its ability to attenuate effect of HFD.