For the treatment or management of diseases, oral administration has received much more attention since the ancient decade. A new concept in oral administration are orodispersible tablets (MDT), which are now widely accepted. Orodispersible tablets are solid dosage forms that, when placed in the mouth, disintegrate and dissolved, release active agent within a few minutes without the need of water. It is more relevant for geriatric, pediatric, bedridden because they have swallowing problem and dysphasia patients. It is more useful for travelers and busy patients who do not have easy access to water. Tablets that dissolve in the mouth are prepared by various technologies with the help of superdisintegrants. Orodispersible tablets are more reliable than conventional dosage forms such as tablets, capsules because of better patient compliance. Advances in this field allow the development of an economical and better way to manage the disease, eliminating several problems associated with other delivery systems.