International Journal of Pharmaceutical Science and Research

Authors
Prajapat Priyanka, Agrawal Dilip, Bhaduka Gaurav

Abstract
Sustained release allows the delivery of a specific drug at a programmed rate that results in drug delivery over a longer period of time. Drug release approach is particularly useful for drugs that are metabolized too quickly and are eliminated from the body shortly after administration. For the internal route of administration, oral drug administration remains the best and most convenient for the administration of various drugs. Gradual release is also suitable for overcoming the side effects of the drug and also for increasing the therapeutic efficacy of the drug. A constant dose of a drug within a therapeutic window is beneficial, for example, in the treatment of cancer. When a drug is dissolved in an aqueous body fluid, it can be readily transported with the fluid to target receptors. Some studies have shown that one way to achieve sustained drug release is to prevent the drug molecules from fully entering the aqueous environment for a manageable amount of time. The basic concepts of a sustained drug delivery system optimize various parameters such as biopharmaceutical, pharmacokinetic and pharmacodynamic properties of a drug to maximize therapeutic efficacy.