Noisome have a important role in drug delivery because they can reduce toxicity and modify pharmacokinetic and bio-availability. Topically applied noisome can enhance the residence time of drugs in the stratum corneum and epidermis, while reducing the systemic absorption of the drug. Niosomal gel dermal drug delivery act as drug containing reservoirs and the modification of the vesicular compositions or surface properties can adjust the drug release rate and the affinity for the target site. Niosomal gel drug delivery beneficial in the treatment of superficial and systemic fungal infections. niosomal gel can be applied by ocular route.