Piper betel L. belongs to family Piperaceae commonly known as Pan. plants whose leaves and seeds are used in combination for chewing purposes throughout wide areas of southern Asia and the East Indies. The betel leaves are nutritive and contain anti carcinogens showing promise for manufacturing of a blood cancer drug and various pharmacological activity shows like anticancer, anti-diabetes, anti-inflammation, analgesic and cooling properties. The present review aims to compile medicinal values of Piper betel generated through the research activity using modern scientific approaches and innovative scientific tools. Though its primary purpose is to be used as a mouth freshener, many people also use it for the numerous health benefits that it provides.