Review of Histone deacetylase (HDAC) inhibitors in treatment of chronic diseases
Fadil Mohsen Hamed, Athraa Hameed Mekky, Bassam A Hassan
Histone deacetylase (HDACs) are conserving evolutionary enzymes that work by removing acetyl groups from histones and other protein regulatory elements, with functional effects on chromatin remodel and gene express patterns. Here, we present a review of the mostly recent information on the zinc-dependent HDAC protein family that has been accumulated across several animals, tissues, and human disorders, with an emphasis on the function of HDAC inhibitors as anticancer drugs. We will look at the chemical differences between various HDACs and talk about how they participate in chromatin-binding and regulatory complexes in the human interactome.
Fadil Mohsen Hamed, Athraa Hameed Mekky, Bassam A Hassan. Review of Histone deacetylase (HDAC) inhibitors in treatment of chronic diseases. International Journal of Pharmaceutical Science and Research, Volume 7, Issue 3, 2022, Pages 7-16