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VOL. 6, ISSUE 4 (2021)
Design, synthesis, characterization and biological evaluvation of indole derivate as antitubercular agents
Authors
J Sridharan, J Banurekha, S Ruby, M Kumar, B S Venkateswarlu, M Saravanan
Abstract
Tuberculosis is a chronic granulomatous disease which is a major health problem in developing countries. The Anti-tubercular drugs for the treatment of Tuberculosis are complicated by the existence of Multi Drug Resistance (MDR) tuberculosis, Extensively Drug Resistance (XDR) tuberculosis and Totally Drug Resistant (TDR) tuberculosis. In this research work, indole derivative. Anti-tubercular activity was evaluated against Mycobacterium tuberculosis Compounds, synthesized in the present investigation were screened for anti- tubercular activity against M. tuberculosis H37Ra strain (Mycobacterium tuberculosis H37 Ra is an attenuated tubercle bacillus closely related to the virulent type strain MTB H37Rv) in the Middlebrook7H9 (MB 7H9 broth) by using Isoniazid as standard drug at a concentration of 25μg/ml. In the present study, the synthesized compounds (a,) show promising activity between 6.25μg/ml to 1.6μg/ml against Mycobacterium tuberculosis were performed.
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Pages:12-17
How to cite this article:
J Sridharan, J Banurekha, S Ruby, M Kumar, B S Venkateswarlu, M Saravanan "Design, synthesis, characterization and biological evaluvation of indole derivate as antitubercular agents ". International Journal of Pharmaceutical Science and Research, Vol 6, Issue 4, 2021, Pages 12-17
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