A systematic review on colon targeted drug delivery system

Hitendra S Chaudhari; Nishant M Patel; Amitkumar R Dhankani; Rupesh D Savale; Mayuresh P Rajurkar

A systematic review on colon targeted drug delivery system

Authors
Hitendra S Chaudhari, Nishant M Patel, Amitkumar R Dhankani, Rupesh D Savale, Mayuresh P Rajurkar

Abstract
In the recent year colonic drug delivery has gained importance for delivery of drug for the treatment of local diseases associated with colon and systemic delivery of therapeutic peptides and proteins. Treatment could be more effective if it is possible for drug to be directly delivered to colon. In past various traditional approaches used for colon targeted delivery like prodrugs, pH dependent system, azo polymeric coating, etc. have achieved limited success. For successful colon targeted drug delivery, the drug needs to be protected from absorption and/or the environment of the upper gastrointestinal tract and then be abruptly released into the colon. Hence continuous efforts have been made on designing colon targeted drug delivery systems with improved site specificity and versatile drug release kinetics to fulfill different therapeutic needs. As the year passes few new systems have been developed for colon targeted drug delivery such as pressure dependent systems, pectin and galactomannan coating, CODES^TM technology, etc. which are reported to have better in-vivo site specificity and design rationale than the earlier approaches. An attempt has been made in this review article to discuss in brief about introduction, need, advantages, disadvantages, various approaches and evaluation of colon targeted drug delivery system.

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