Curative anti-oxidant potential of Psidium guajava stem-bark extract on animal model

Benjamin Ogunma Gabriel; Asuelimen Osagie Steve; Otakhor Kelly Osayi; Daniel Edeha Okiemute; Iyamu Osamudiamen Courage; Owen Obaseki Edehia

Curative anti-oxidant potential of Psidium guajava stem-bark extract on animal model

Authors
Benjamin Ogunma Gabriel, Asuelimen Osagie Steve, Otakhor Kelly Osayi, Daniel Edeha Okiemute, Iyamu Osamudiamen Courage, Owen Obaseki Edehia

Abstract
Psidium guajava elicited important functions in the management of several disease condition as proved by traditional medicine practitioner. This study investigate the curative anti-oxidant potential of P. guajava stem-back aqueous extract. Twenty five Wistar rats were randomly selected into ten groups (n=5). The curative study involved the untreated control that received 40 % ethanol, normal control was administered with 0.5 ml distilled water and tested groups at graded doses where administered with 50, 100 and 200 mg/kg P. guajava stem-back aqueous extract after 40 % ethanol where administered orally for 14 days prior to treatment across the groups. In-vivo antioxidant study of enzymatic and non-enzymatic antioxidant elicited a significant increase in Superoxide dismutase of plasma and tissue homogenates across the tested groups with the highest significant values at (4.93; 4.07; 2.41; 4.63; 3.51 U/ml), reduced glutathione at (4.58; 2.60; 2.49; 4.37; 2.69 U/ml), catalase at (289.87; 126.00; 126.97; 244.28;121.94 U/ml) and glutathione peroxidase (1.97; 2.10; 2.26; 2.06; 2.04 U/ml) when compared with untreated control (p<0.05) with decreased in the level of MDA at (18.74; 16.02; 15.81; 17.78; 14.33 U/ml) when compared with untreated control at (32.01; 35.17; 29.74; 31.85; 29.75 U/ml) of antioxidant indexes in plasma, liver, kidney, heart and lungs homogenates thereby scavenging or eliminating free radicals when compared with untreated control and vitamin C control. In conclusion, Psidium guajava elicited neproprotective, hepatoprotective and bio-protective effect of visceral organs via antioxidant scavenging property.

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