International Journal of Pharmaceutical Science and Research

Authors
R Abilash, Mohammed Shadab Pasha, Sumithra Devi

Abstract
The present investigation was aimed to formulate and evaluate the gastro-retentive floating microspheres of glipizide using hydrophilic polymers such as hydroxy propyl methylcellulose (HPMC) and Ethyl cellulose by solvent evaporation technique. The floating microspheres were evaluated for micromeritic properties, scanning electron microscopy, Incorporation efficiency, percentage yield, buoyancy and in vitro drug release. From the results of studiesit shows that formulation F9 was found to be satisfactory in terms of excellent micromeritic, Incorporation efficiency 96.38±2.84% percentage yield 93.780±0.55% in-vitro buoyancy 94.95±1.07% and in vitro drug release 94.60978±1.00%. The scanning electron microscopy confirmed the hollow nature of microspheres with pores on the surface which imparted floating properties to the prepared floating microspheres. Among all the developed formulations, F9 was found to be the best as it exhibited highest drug release (94.60%) in 12 hr.