Liver an accessory digestive organ present in vertebrates results in detoxification of the metabolites, synthesis of protein, generation of necessary biochemicals such as bile, as well an energy reservoir in form of glycogen. Liver disease also named as hepatic disease creates a toll in the hepatic management causing an effect on overall functions of Liver. The motto of our present study is based on the hepatotoxicity management of liver based on traditional herbal medicine. Liver diseases has hundreds of symptoms among which we addressed specifically oxidative stress, anomaly in protein distribution, fat related peripheral catabolism, concurrent viral hepatitis, increased redox ratio, retention of liver cell water and viral proteins, effected cell mediated immunity, fibrogenesis, and inflammation. This review article describes the various natural resources (plant extracts) of diverse families having hepatoprotective effects and the active constituents responsible for it.