International Journal of Pharmaceutical Science and Research

Authors
Lakhvir Kaur, Gurjeet Singh, RK Dhawan

Abstract
The proposed research work is described two simple, economic and fastsimultaneous quantitation of levocetirizine dihydrochloride and phenylephrine hydrochloride in solid dosage forms. Both proposed methods based on spectrophotometric analysis. First developed method is vierodt’s method. It is based on solving the simultaneous equation while second method based on 1^st order derivatization. First method employs formation of simple simultaneous equation using 231.0nm and 273.0nm as two analytical wavelengths for levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. Two analytical wavelengths were selected at 239.0nm & 225.5nm after derivatization of spectra for simultaneous studies of levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. The drugs obeys lambert- beer’s law in the range of 2-32 µg/ml and 6-120 µg/ml& 5-90 µg/ml and 5-100 µg/ml for levocetirizine dihydrochloride and phenylephrine hydrochloride for I& II methods. Validation of the proposed methods was carried out for its accuracy, precision, specificity, ruggedness, LOD, LOQ according to ICH guidelines.