International Journal of Pharmaceutical Science and Research

Authors
Madan L Kaushik, SP Gautam

Abstract
Curcuma zedoaria Rosc (CZ) is commonly known as white turmeric useful in crippling arthritic and frozen joint in traditional Siddha medicine. The aim of study was to investigate the potential anti-arthritic effects of petroleum ether, chloroform and ethanol extracts of C. zedoaria roots on Freund’s complete adjuvant-induced arthritis in rats. The CZ roots powder was successive extracted with petroleum ether, chloroform and ethanol. The paw volume and body weight were measured by using a Plethysmometer on 0, 3, 7, 14, 21 and 28 days. Hematological parameters, vascular permeability and histopathology were carried out at 28 days. The results indicate that regular treatment of CZ root extracts showed significant decrease paw edema from 3 to 28 days in all groups. Petroleum ether, chloroform extract and ethanol extract showed that test drug treated groups achieved near to the normal value of ESR, Hb, RBC and WBC. The serum nitric oxide and vascular permeability showed significant inhibitory effects. Histopathology examinations were showed protective effects in the joint of all treated groups compared with the control group. The data suggest that petroleum ether, chloroform and ethanol extract 200 mg/kg produced significant anti-arthritic effects and petroleum ether 200 mg/kg showed highly effective against arthritis.