The Calotropis procera, Aegle marmelos, Annona squamosa is a typical no man's land plant and known for different restorative properties. The point of present examination was to screen the leaves of Calotropis procera, Aegle marmelos and Annona squamosa for the antimicrobial movement against clinical segregates of bacteria; Staphylococcus aureus. The detailed cleaning in powder was read for its hostile movement against Staphylococcus aures. The in vitro antimicrobial action was performed by utilizing agar dissemination technique. The definitions shows critical impact on the tried living being and the phytochemical study uncover the nearness of tannins, alkaloids in these three leaves. The tidying powder can be utilized to treat skin diseases and tingling.