International Journal of Pharmaceutical Science and Research

Authors
Rahul Nair, M Gopal Rao

Abstract
Polymeric matrix type Levetiracetam transdermal patches were prepared by solvent casting method using combination of PVP and PVA in varying ratio with plasticiser glycerol and permeation enhancers DMSO and DMF, which exhibited good flexibility, proper physio-mechanical characteristics, handling properties and drug release. Based on the physicochemical parameters and in vitro release studies, the F15 formulation with PVP and PVA in the ratio 4:1 with glycerol and DMSO as a permeation enhancer showed the best results, which exhibited the cumulative percentage of drug release of 40.34% in 24 hrs. The drug release of transdermal formulations followed Higuchi’s model kinetics and Fickian diffusion.