Atopic dermatitis (AD) is a chronic and relapsing disease affecting an increasing number of patients. It is a common inflammatory condition of the skin that is usually seen in childhood, but can onset or persists into adulthood. Atopic dermatitis (AD) has a prevalence of 1%-3% in adults and 10%-20%, in children. Environmental factors or genetic-environmental interactions seem to play a key role in disease progression. AD is often found in individuals with a personal or family history of atopy, including allergic rhinitis, asthma and AD. Signs and symptoms of AD: pruritus, dry skin, edema, excoriations, lichenification and oozing. AD’s presentation may vary depending on the patient’s age, disease severity and chronicity. Recently, more attention is given to a proactive therapeutic by regular intermittent application of low potency steroids or topical calcineurin inhibitors to prevent new flares. Principle of treatment in Unani medicine is based on multidimensional approach i.e. Ilaj Bil Ghiza, Ilaj Bil Tadbeer and Ilaj Bil Dawa.