Mouth dissolving tablets (MDTs) are novel dosage forms containing drugs that disintegrate in the oral cavity within less than one minute leaving an easy-to-swallow residue. In the current trend the development of mouth dissolving tablets formulation is originate and gaining popularity because these tablets dissolve in the mouth within a few seconds without the help or need of any drinking agent like water. These tablets achieves the higher concentration in the body to provide the immediate action. Recently, the oral delivery is the gold standard in the pharmaceutical industry because it is the easiest, safest, economical and convenient method for the drug delivery and having highest patient compliance. Mouth dissolving tablets are suitable for the pediatric, geriatric, bedridden, mentally disabled patients and for active patients who are busy and traveling and may not have access to water and these will show the effective action in few minutes. Here in this article, we mainly highlights on, advantages, disadvantages, main ingredients, mechanism of action of disintegrants, approaches for preparation, patented technologies, evaluation parameters of mouth dissolving tablets.