Some researchers have conducted a research relating to the pharmacological effects of mangosteen rind; it was found that the xanthon compounds contained in mangosteen rind have varied pharmacological effects. From the studies that have been conducted, it is proven that mangosteen rind has many benefits and potential for treatment, one of which is as an antimicrobial. Chitosan is a derivative of chitin, commonly found in invertebrates such as Crustacea sp and cuticle insects. Chitosan has good potential in supporting the preparation of drug preparations, both in the form of tablets, hydrogels, microparticles and nanaoparticles. Chitosan is a biopolymer that has extraordinary properties, namely non-toxic, easily found, good biodegradation and biocompatibility, and can increase the bioavailability of drug preparations as well. Chitosan can be used in the manufacture of pharmaceutical preparations that has purpose to prevent or treat a disease because chitosan is known to have antimicrobial properties. Mangosteen rind (Garcinia mangostana L) and chitosan are proven to have antimicrobial activity. However, mangosteen rind and its derivatives have low solubility. The increasing of solubility can be done by designing it into the form of nanoparticles using chitosan polymers that have good physical chemical characteristics so that they can be used as polymers that can act as drug delivery in anticancer, antifungal and antibacterial treatment. The addition of chitosan is used as a conductor and protective drug, so that the drug is not easily degraded due to environmental conditions in the patient's body and can work specifically on the target work of the drug.
Jamila Fachrunnisa Kabakoran, Muchtaridi Muchatridi. Effectiveness of mangosteen rind (Garcinia mangostana Linn.) and chitosan polymers as an antimicrobial. International Journal of Pharmaceutical Science and Research, Volume 4, Issue 3, 2019, Pages 79-83