Oral route of drug administration is the most convenient method of administering drugs. Among the oral route of drug administration solid oral dosage forms represent the most preferred dosage form. Oral solid dosage forms facilitate accurate dosing of drugs compared to oral liquid dosage forms. Patient’s compliance is better due to the convenience of self administration of drugs. Oral dosage form is broadly classified into two categories: Single-unit and Multiple-unit dosage forms. The basic concept of multiple-unit systems is that the dose of active ingredient is released by the individual subunits and the functionality of the entire dose depends on the quality of the subunits. Micro tablets are tablets with a diameter to or smaller than 2 to 3 mm. The main advantage of micro tablets over other dosage forms is less chances of gastric irritation and dose dumping. It has advantage over pellets in more accuracy in drug content and ease of manufacturing. The present study is aimed at developing micro tablets with 2mm diameter of combinational product of Amlodipine and Valsartan. The current research is aimed at developing an estimation method for quantification of Amlodipine and Valsartan from micro tablets in a capsule.