International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 3, Issue 4 (2018)

Formulation, development and evaluation of clindamycin phosphate microspheres for topical delivery system


Kanchepogu Madhavi, Biswa Mohan Sahoo, Y Tejo Kumar

The aim of the present study was to formulate topical microspheres based delivery system containing Clindamycin for treatment of infections. The microsphere was prepared by double emulsion solvent diffusion method. Then after the optimized batches incorporated into gel base. Clindamycin phosphate is lincosamide antibiotic and is used mainly for treatment of acne. The microspheres of the optimum batch (N5) exhibited 79.1% drug entrapment efficiency, mean particle size of 310 ┬Ám and 94.96% release at 8 hour. An appropriate balance between the levels of the polymer (EC) and stirring speed was imperative to acquire maximum drug entrapment efficiency, control release of the drug, and adequate particle size. The optimize batch was further used for antimicrobial study and skin irritation study and also compared with marketed gel clindawel. Antimicrobial study was performed on nutrient agar media for S.epidermidis and agar media for P. acne because of both of microbes responsible for production of acne. The zone of inhibition of formulated gel against S.epidermidis and P.acne microbes was greater than marketed gel.
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How to cite this article:
Kanchepogu Madhavi, Biswa Mohan Sahoo, Y Tejo Kumar. Formulation, development and evaluation of clindamycin phosphate microspheres for topical delivery system. International Journal of Pharmaceutical Science and Research, Volume 3, Issue 4, 2018, Pages 31-34
International Journal of Pharmaceutical Science and Research