Aims and Objectives: This study was undertaken with the objective of evaluating the analgesic activity of Capsicum chinense in experimental animals. Material and Methods: Ethical review: The present study was performed on mice (20-30 gm body weight) of both sexes. Plant material: Whole plant of Capsicum chinense will be collected and authenticated. Extraction of plant material: The shade dried and finely powdered fruits were extracted with 99.9% ethanol using Soxhlet apparatus. Acute toxicity study: Acute toxicity study was carried out according to the OECD 425 Guidelines. Experimental design: Group 1- Normal Control- Received Normal Saline at a dose of 10ml/kg per orally, Group 2- Disease Control- Acetic Acid 1% (1ml/100gm) i.p., Group 3- Standard- Diclofenac at a dose of 10 mg/kg i.p. + Acetic Acid 1% (1ml/100gm) i.p., Group 4- EECC 200 mg/kg per orally + Acetic Acid 1% (1ml/100gm) i.p., Group 5- EECC 400 mg/kg per orally + Acetic Acid 1% (1ml/100gm) i.p. Test for peripherally acting analgesic: Acetic acid induced writhing. Diclofenac was used as standard in this test.