An increased evidence of positive effects of phytochemicals in disease prevention has lead to scientific analysis of many plant materials for their bioactive constituents. Sea buckthorn (SBT) is known to be a good source of antioxidants and other bioactive components which have been found to exert positive effects on human health. A number of pharmacological activities such as cytoprotective, anti-stress, immunomodulatory, hepatoprotective, radioprotective, anti-atherogenic, anti-tumor, anti-microbial and tissue regeneration have been reported in seabuckthorn. Bioactive compounds present in Seabuckthorn may serve as good ingredients for development of functional foods.