Commelina apendiculata is an annual herb and highly distributed in Eastern India, Sri Lanka and Bangladesh. Many plants of this genus are used in medicine for the treatment of inflammation, pain, fever, dysentery, diarrhea, diabetes, neurological disorders, cancer, toxicity, heart diseases, asthma, oxidative stress etc. Plants belonging to the genus Commelina have been shown to contain coumarins, anthocyanin, alkaloids, terpenoids, steroids, iridoids, flavonoids and some other molecules such as aliphatic alcohols, polyols and phenolic acids. Here, we have reviewed all the reported pharmacological properties such as analgesic, cytotoxic activities, sedative and anti-diarrheal activities of Commelina appendiculata.