International Journal of Pharmaceutical Science and Research

Authors
Karthikeyan M, Balasubramanian T, Pawan Kumar

Abstract
Objective: The aim of the present study is to study the effects of ethanolic extract of Premna coriacea on Oral Glucose Tolerance Test (OGTT) in diabetic rats. Methods: Acute oral toxicity test was performed based on OECD guidelines, with reference to behavioural aspects, in Swiss Albino mice. Oral Glucose Tolerance Test are carried out in diabetic rats, Spargue Dawley male rats weighing 140-280 gm were divided into 7 groups consisting of 5 rats in each group. After 60minutes of drug administration, the rats were orally treated with 2g/kg of glucose. The blood samples were collected through femoral vein at 0,15, 30, 60, 120 minutes. Blood glucose level was estimated at various time intervals. Results: PCEE did not produce any mortality and sign of lethality throughout the study period of 14 days. Normal control from 155 to 103 mg/dl, disease control from 715 to 496 mg/dl, PCEE 180 to 147 mg/dl, PCEE from 198 to 116 mg/dl and Standard 234 to 127 mg/dl Conclusion: The toxicity study reveals that the extract is nontoxic and can be used in further bioactivity test. The study reveals the positive effect of extracts in maintaining glucose homeostasis in rats.