International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 3, Issue 1 (2018)

Synthesis and Antiproliferative activity of novel Acridine-biotin conjugates


Shaban El Khabery, Mohamed A El-Bahnsawye, Ahmed Abdel Aleem El-Gokha, Amira A Salama, Ibrahim El-Tantawy El Sayed

Acridine-biotin conjugates 7 were synthesized in good yields by coupling aminoalkylaminoa acridines 5 with biotin 6. The key starting diamines 4 were synthesized by reaction of 9-chloroacridine 3 with diamines 4. The structure of the synthesized compounds were elucidated by the spectroscopic tools and showed results consistence with the proposed structures. Furthermore, the antiproliferative activity for the synthesized compounds were evaluated against hepatocellular (HepG2), colon (HCT-116) and breast (MCF-7) carcinoma cell lines using colorimetric MTT assay. The screening results showed that compound 7l exhibits the best activity with IC50: 5.99, 8.84 and 7.80 ┬ÁM against HepG2, HCT-116 and MCF-7 cancer cell lines respectively.
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How to cite this article:
Shaban El Khabery, Mohamed A El-Bahnsawye, Ahmed Abdel Aleem El-Gokha, Amira A Salama, Ibrahim El-Tantawy El Sayed. Synthesis and Antiproliferative activity of novel Acridine-biotin conjugates. International Journal of Pharmaceutical Science and Research, Volume 3, Issue 1, 2018, Pages 18-23
International Journal of Pharmaceutical Science and Research