Green chemistry does not means Green as a color but an alternative to design of chemical products and processes that reduce, minimize or eliminate the use and generation of hazardous substances. Green chemistry is based on the fundamental or outstanding principles that when implemented right will maximize the incorporation of raw materials into the final products with environmentally-friendly substances and methodologies. The use of solvents and catalysts as greener technologies are emphasized. In pharmaceutical industry, some drugs generate large amount of waste as byproducts during their synthesis which results the low yield in the final products. In this review, the green alternative pathway of Acetaminophen (paracetamol) and Ibuprofen among other were reported.