Clerodendrum genus l. Belongs to a family of Lamiaceae. Clerodendrum broadly spread in subtropical as well as in tropical areas of this world. Almost about 500 species belongings to the genus Clerodendrum of that are recognized till yet. More than five hundred species of Clerodendrum genus comprises small herbs, shrubs, and trees. Numerous species of Clerodendrum genus exhibited its medicinal significance that had been described in several native schemes of drugs as well as in several traditional medications. For the curing of a number of natural life menacing ailments i.e. Syphilis, typhoid, cancer, jaundice and hypertension genus Clerodendrum is being used as in medicines specifically in different countries like Japanese, Thai, Indian, Chinese and Korean systems of medication. Clerodendrum genus has also been extensively studied for various biological activities to know its potential effect towards pharmaceutics. Several studies had been also reported the isolation as well as chemical constituents’ identification and its association with the biotic activities of the Clerodendrum genus. Chief chemical constituents that were described in numerous reported studies of the genus are volatile oils, steroids, diterpenoids, triterpenoids, flavonoids and phenolic compounds.