Aim of the study: The study investigates on methanolic extract of Artocarpus heterophyllus leaves for antipyretic potential in wistar rats.

Materials and methods: Fever was induced by administration of Typhoid, Para-typhoid A and B vaccine, diluted in 1/15 th part of saline, intra peritonially. The hyperexia in rats was measured using thermometer. Methanolic extract of Artocarpus heterophyllus leaves of dose 100, 200 and 400 mg per kg-1 body weight was administered to animals.

Results and Discussion: Methanolic extract of Artocarpus heterophyllus leaves of dose 400mg per kg-1 body weight produced significant reduction in elevated body temperature compared to that of standard Paracetamol 150 mg per kg-1 body weight. The obtained values are expressed as mean±SEM values. Conclusion: Our results provides information regarding safety and effectiveness of Artocarpus heterophyllus leaves extract in treatment of fever.