International Journal of Pharmaceutical Science and Research

International Journal of Pharmaceutical Science and Research


International Journal of Pharmaceutical Science and Research
International Journal of Pharmaceutical Science and Research
Vol. 1, Issue 7 (2016)

A review: Imidazole synthesis and its biological activities


Purnima Manocha, Dr. SR Wakode, Avneet Kaur, Keshav Anand, Hitesh Kumar

Imidazole is a planar five- member heterocyclic ring with 3C and 5N atom with N atom present at the 1st and 3rd positions of the ring. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. The high therapeutic properties of the imidazole related drugs have encouraged the medicinal chemists to synthesize a large number of novel chemotherapeutic agents. Imidazole is an entity which explores different types of pharmacological and biological activities like metronidazole and nitrosoimidazole as bactericidal, 1­vinylimidazole as fungicidal, megazol as trypanocidal, imidazole­2­one as antileishmanial and other antimicrobial activities. This article aims to review the process of synthesis of imidazole and its derivatives by different methods and pharmacological activities
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How to cite this article:
Purnima Manocha, Dr. SR Wakode, Avneet Kaur, Keshav Anand, Hitesh Kumar. A review: Imidazole synthesis and its biological activities. International Journal of Pharmaceutical Science and Research, Volume 1, Issue 7, 2016, Pages 12-16
International Journal of Pharmaceutical Science and Research International Journal of Pharmaceutical Science and Research