A novel PVC membrane sensor for tranexamic acid based on Tranexamic acid phosphotungstate ion pair complex was prepared. The influences of membrane composition (i.e. percent of ion-pair complex, PVC, kind of plasticizer and ionic additive), inner solution, pH of test solution and foreign cations on the electrode performance were investigated. The optimized membrane demonstrates Nernstian response (56.2 ±0.4 mV per decade) for tranexamic acid cations over a wide linear range from 1.0×10^-5 to 1×10⁻² M at 25^oC with lower detection limit 8.0×10^-6 M. The potentiometric response is independent from the pH of the solution in the pH range of 2.0-4.5. The proposed sensor has the advantages of easy preparation, fast response time. The selectivity coefficients indicate excellent selectivity for tranexamic acid over many common cations (e.g., Na⁺, Cu²⁺, Ni²⁺, vitamin k₁ and gabapentin). The sensors are used successfully for the determining of tranexamic acid in pure form and pharmaceutical preparations.